The 'Group' letters/numbers that you see throughout this web site refer to the classification of herbicides by their site of action. To see a full list of herbicides and HRAC herbicide classifications click here.
QUIK STATS (last updated Feb 02, 2023 )
NOTES ABOUT THIS BIOTYPE
First report on resistance to HPPD herbicides mediated by nontarget-site mechanisms in the grass Leptochloa chinensis. Author(s) : Ju BoMing ; Liu Min ; Fang YuHang ; Liu LeiCheng ; Pan Lang Author Affiliation : Hunan Agricultural University, Changsha 410128, China.
Author Email : email@example.com
Journal article : Journal of Agricultural and Food Chemistry 2023 Vol.71 No.46 pp.17669-17677
Abstract : The emergence of 4-hydroxyphenylpyruvate dioxygenase (HPPD) herbicides as efficacious target-site herbicides has been noteworthy. In recent years, only four species of broadleaf weeds have developed resistance due to the long-term widespread use of HPPD herbicides. This study represents the first reported instance of a grass weed exhibiting resistance to HPPD inhibitors. We identified a new HPPD-resistant Chinese sprangletop [Leptochloa chinensis (L.) Nees] population (R population). At the recommended dose of tripyrasulfone, the inhibition rate of the R population was only half that of the sensitive population (S). The mechanism underlying resistance does not involve target-site resistance triggered by amino acid mutations or depend on disparities within the HPPD INHIBITOR SENSITIVE 1 (HIS1) gene. The impetus for resistance appears to be interlinked with the metabolic activities of cytochrome P450 monooxygenase (P450) and glutathione S-transferase (GST) family genes. Following RNA sequencing (RNA-seq) and quantitative real-time PCR (qRT-PCR) validation, the study suggests that five P450 genes, CYP71C1, CYP74A2, CYP72A1, CYP84A1, and CYP714C2, alongside a single GST gene GSTF1, may be implicated in the process of metabolic detoxification. ISSN : 0021-8561 DOI : 10.1021/acs.jafc.3c04323
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